Cellular mechanisms generating bursting activity in neuronal networks
© Cannon et al.; licensee BioMed Central Ltd. 2014
- Published: 21 July 2014
- Neuronal Network
- Transient Response
- Central Pattern Generator
- Burst Activity
- Invariant Circle
An open question in neuroscience is how the temporal characteristics of bursting activity are controlled by intrinsic biophysical characteristics. We present two mechanisms organized around the cornerstone bifurcation in a 3D Hodgkin-Huxley style neuronal model. This bifurcation satisfies the criteria for both the Shilnikov blue sky catastrophe and the saddle-node bifurcation on an invariant circle (SNIC) [1–3]. The burst duration (BD) and interburst interval (IBI) increase as the inverse of the square root of the difference between the corresponding parameter and its bifurcation value. The cornerstone bifurcation also determines the stereotypical transient responses of silent and spiking neurons . The mechanisms presented here are based on these transient responses.
The second mechanism described the bursting activity of two intrinsically spiking, mutually excitatory neurons. The parameters of the neurons were in vicinity of the cornerstone bifurcation. This network exhibited synchronized bursting (Figure 1CD). Remarkably, excitatory interaction between endogenously spiking neurons essentially led to reduction of excitability of the network. When the half-activation voltage of hyperpolarization-activated current (V1/2,mh) was systematically shifted to the bifurcation value, IBIs of both neurons increased in accordance with the inverse-square-root law and the BDs and the number of spikes per burst stayed constant (6 spikes per burst).
This study reveals new mechanisms controlling bursting activity in small neuronal networks based on cellular properties determining transient responses of endogenously spiking and silent neurons. These mechanisms are generic and could govern the bursting regimes in rhythmic neuronal network such as central pattern generators.
The authors acknowledge support from the NSF grant PHY-0750456.
- Shilnikov L, Shilnikov A, Turaev D, Chua L: Methods of Qualitative Theory in Non-linear Dynamics. 2001, World Scientific: 1998, 1-2.Google Scholar
- Shilnikov AL, Cymbalyuk GS: Transition between tonic-spiking and bursting in a neuron model via the blue-sky catastrophe. Phys Rev Lett. 2005, 94: 048101-View ArticlePubMedGoogle Scholar
- Barnett W, Cymbalyuk G: A codimension-2 bifurcation controlling endogenous bursting activity and pulse-triggered responses of a neuron model. PLoS One. 2014, 9: e85451-10.1371/journal.pone.0085451.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.