Figure 1
From: Modeling mGluR1 mediated synaptic depression in cerebellar Purkinje cells
Local model constructed to simulate fEPSP depression triggered by TRPC channel current. A. TRPC channel current (Ik) increase due to activation of mGluR1 is linked to AMPA channel conductance (gmax) to simulate the decrease of the channel density. B. fEPSPs are evoked randomly at 1 Hz to monitor the amplitude change of the depression effect caused by TRPC current (Ik).