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Table 2 Average concentration of Fe, Cu, Zn and Mn in small hippocampal regions of the brain

From: Simultaneous monitoring of cerebral metal accumulation in an experimental model of Wilson’s disease by laser ablation inductively coupled plasma mass spectrometry

μg g−1wet weight Control WD % change p- value
Fascia dentata, layers
 Moleculare
  Fe 13.1 ± 2.1 14.6 ± 1.2   .1
  Cu 5.2 ± 1.2 8.9 ± 1.2 +71% .00001
  Zn 14.0 ± 3.7 19.4 ± 1.3 +38% .004
  Mn 0.34 ± 0.10 0.32 ± 0.07   .9
 Granulare
  Fe 18.4 ± 3.4 16.3 ± 2.1   .2
  Cu 4.1 ± 1.1 7.6 ± 1.0 +86% .00001
  Zn 25 ± 7 32 ± 3 +30% .02
  Mn 0.39 ± 0.14 0.39 ± 0.09   .7
 Multiforme /polymorph
  Fe 12.9 ± 1.7 13.2 ± 0.8   .7
  Cu 4.1 ± 1.2 8.0 ± 1.5 +95% .0001
  Zn 47 ± 14 59 ± 9 +24% .1
  Mn 0.48 ± 0.28 0.48 ± 0.14   .8
Cornu ammonis, layers
 Oriens
  Fe 10.8 ± 1.2 10.6 ± 1.0   .7
  Cu 3.8 ± 0.8 6.6 ± 1.4 +75% .0002
  Zn 18.0 ± 4.0 20.8 ± 3.8   .2
  Mn 0.26 ± 0.06 .32 ± 0.08   .04
 Pyramidale, CA3
  Fe 11.3 ± 1.9 12.3 ± 1.4   .3
  Cu 4.6 ± 1.4 7.0 ± 1.2 +52% .003
  Zn 33 ± 10 38 ± 5.5   .2
  Mn 0.45 ± 0.20 0.48 ± 0.13   .5
 Pyramidale, CA1-2
  Fe 19.0 ± 3.7 15.1 ± 1.5   .03
  Cu 3.5 ± 1.0 5.9 ± 0.9 +69% .0002
  Zn 20.9 ± 4.8 24.4 ± 3.4   .1
  Mn 0.27 ± 0.07 0.33 ± 0.06   .04
 Radiatum
  Fe 10.5 ± 1.5 10.2 ± 0.7   .7
  Cu 3.2 ± 0.8 6.3 ± 1.2 +92% .00002
  Zn 21.8 ± 4.9 23.8 ± 3.0   .3
  Mn 0.25 ± 0.06 0.31 ± 0.08   .04
 Lacunosum- moleculare
  Fe 12.8 ± 2.1 12.2 ± 1.3   .6
  Cu 3.6 ± 0.9 5.6 ± 1.0 +53% .001
  Zn 14.1 ± 3.7 18.4 ± 1.5 +30% .01
  Mn 0.28 ± 0.08 0.29 ± 0.06   .4
 Subiculum
  Fe 14.4 ± 2.3 12.9 ± 1.4   .2
  Cu 3.4 ± 0.9 5.9 ± 1.1 +72% .0001
  Zn 15.4 ± 4.1 17.4 ± 1.6   .2
  Mn 0.23 ± 0.06 0.27 ± 0.03   .7
 Praesubiculum
  Fe 13.9 ± 3.2 13.8 ± 1.5   1
  Cu 4.8 ± 1.4 7.8 ± 1.4 +62% .0006
  Zn 13.1 ± 3.0 16.3 ± 1.0 +25% .02
  Mn 0.23 ± 0.07 0.26 ± 0.05   .2
  1. Concentrations of Fe, Cu, Zn, Mn (mean ± SD) measured by LA-ICP-MSI in subregions of the hippocampal formation. Layers are given in the order from outside to inside.