Figure 1

Potential target genes of Sox2-Grg interaction. (A) Scheme of the experiment using microarray analysis to identify genes affected by Sox2 in human NSCs. (B) The relative percentage of genes affected by Sox2 as compared to control cells transfected by GFP alone (only differences of above 1.5-fold were included in both comparisons). (C) Graph representing the most activated (bars to right of midline) and repressed (bars to left of midline) genes. (D) The genes most strongly repressed by Sox2 in our study that were also suggested to be repressed by Sox2 in mouse ES cells (Masui et al. [6]), or in human ES cells (Greber et al. [7]). Final column indicates the study in which these were also shown to be direct targets of Sox2.