Figure 6

Ultrastructural analysis of mitochondrial structure in Tau/GSK3β bigenic mice. (A) Ultrastructural analysis of mitochondrial structure in vehicle-treated and CBL treated non-tg mice. (B) Ultrastructural analysis of mitochondrial structure in vehicle-treated Tau/GSK3β bigenic mice, boxes in upper panel are shown at a higher magnification in the lower panels. (C) Ultrastructural analysis of mitochondrial structure in CBL-treated Tau/GSK3β bigenic mice. (D) Quantitative analysis of number of small mitochondria (less than 5 μm) in vehicle and CBL treated Tau/GSK3β bigenic mice in comparison to non-tg mice. (E) Quantitative analysis of number of dividing mitochondria in vehicle and CBL treated Tau/GSK3β bigenic mice in comparison to non-tg mice. (F) Quantitative analysis of number of mitochondrial inclusions in vehicle and CBL treated Tau/GSK3β bigenic mice in comparison to non-tg mice. Scale Bar = 0.5 μm, error bars represent mean ± SEM (n = 6 per group, 6 m/o). *Indicates a significant difference (p < 0.05) between vehicle non-tg mice and vehicle-treated Tau/GSK3β bigenic mice and # indicates a significant difference (p < 0.05) between vehicle and CBL treated Tau/GSK3β bigenic mice analyzed by one-way ANOVA and Dunnett’s post hoc test.