Figure 5From: Sex differences in mitochondrial biogenesis determine neuronal death and survival in response to oxygen glucose deprivation and reoxygenationProtein expression of mitochondrial biogenesis factors in XY and XX CGNs upon exposure to OGD (2 h) and reoxygenation (6–24 h). Western blot analyses of PGC-1α (A) and TFAM (B) were performed using total cellular extracts of XY and XX CGNs from either normoxia control or exposed to OGD/Reox for the indicated time points. Histograms show values for TFAM and PGC-1α normalized to actin. Values are expressed as mean ± SD from four independent experiments (*p < 0.05, ***p < 0.001 XX vs. XY, +p < 0.05, ++ p < 0.01 vs. control, a one-way ANOVA followed by Bonferroni/Dunn post hoc test was applied). Quantification of TFAM and PGC-1α specific bands showed increased expression in XY compared to XX CGNs.Back to article page