Figure 4

Production of cytokines by spleen cells stimulated with MOG. C57BL/6 mice were infected with S. aureus strains, and 3 days later, they were subjected to EAE induction. Cytokine production was tested 30 days after EAE induction. IFN-γ (a), IL-17 (b), IL-5 (c) and IL-10 (d) production were assayed in spleen cell cultures that were re-stimulated in vitro with MOG. Data are expressed as the mean ± SE of 5-12 mice. Different letters represent significant differences between the groups. The statistical analysis (ANOVA or ANOVA on Ranks with Dunn’s method) indicate significant differences between EAE and both infected groups, p<0.05.