Inhibition of the behavioral effects of mirtazapine by prazosin or by clonidine. (A) Beam-walking test: Vertical axis shows the periods required to traverse 50 cm of the beam. (B) Rota-rod test: Vertical axis shows the latency to fall from the rotating rod after the mice were placed on it. Values are expressed as means ± SEM, n = 10 mice/group. Statistical significance was evaluated by one-way ANOVA followed by (A) Student-Newman-Keuls test and (B) Scheffe test (F(A) 4,45 = 15.060, F(B) 4,45 = 13.097, *P < 0.05, **P < 0.01 compared with MPTP-treated group and ††P < 0.01, †P < 0.05 compared with MPTP + mirtazapine group).