Effects of WAY100635, prazosin or clonidine on basal motor activity of normal mice. (A) Beam-walking test: Vertical axis shows the periods required to traverse 50 cm of the beam. (B) Rota-rod test: Vertical axis shows the latency to fall from the rotating rod after the mice were placed on it. Values are expressed as means ± SEM, n = 10 mice/group. WAY, WAY100635; Praz, prazosin; Clon, clonidine. Statistical significance was evaluated by one-way ANOVA followed by Scheffe test (F(A) 3,36 = 14.476, F(B) 3,36 = 27.092, **P < 0.01 compared with vehicle group).