Skip to main content

Table 3 The effect of tau phosphorylation on cell death in the presence of model Hirano bodies

From: Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain

Sample

%Cell death

Hirano body/GSK3β(K85A)

4.20 ± 0.77

Hirano body/G272V

17.90 ± 2.59

Hirano body/G272V/GSK3β(K85A)

10.20 ± 1.35

GFP/G272V

4.75 ± 0.74

GFP/G272V/ GSK3β(K85A)

5.80 ± 0.56

GFP/G272V + GFP/ GSK3β(K85A)

8.95 ± 2.06

  1. Expression of GSK3β(K85A) reduced the synergistic cell death observed when both G272V and model Hirano bodies are present, to an additive effect, implying that the phosphorylation state is important.
Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us