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Table 3 The effect of tau phosphorylation on cell death in the presence of model Hirano bodies

From: Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain

Sample %Cell death
Hirano body/GSK3β(K85A) 4.20 ± 0.77
Hirano body/G272V 17.90 ± 2.59
Hirano body/G272V/GSK3β(K85A) 10.20 ± 1.35
GFP/G272V 4.75 ± 0.74
GFP/G272V/ GSK3β(K85A) 5.80 ± 0.56
GFP/G272V + GFP/ GSK3β(K85A) 8.95 ± 2.06
  1. Expression of GSK3β(K85A) reduced the synergistic cell death observed when both G272V and model Hirano bodies are present, to an additive effect, implying that the phosphorylation state is important.