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Table 2 Additive versus synergistic cell death induced by co-expression of tau and GSK3β (S9A)

From: Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain

Tau % Cell death (Additive) = GFP/GSK3β(S9A) + GFP/tau % Cell death (Actual) = GFP/GSK3β(S9A)/ tau p value
352tauWT 24.1% ± 1.44 57.3% ± 1.74 p < 0.005
441tauWT 24.7% ± 0.95 29.1% ± 2.77 N.S.
352tauPHP 25.5% ± 1.52 49.8% ± 3.63 p < 0.005
R5H 25.1% ± 1.62 43.4% ± 1.37 p < 0.005
K18 25.9% ± 1.40 46.3% ± 2.44 p < 0.005
K18ΔK280 46.4% ± 1.00 76.4% ± 4.84 p < 0.005
P301L 25.2% ± 1.37 55.3% ± 1.45 p < 0.005
G272V 25.8% ± 2.88 27.8% ± 3.13 N.S.
R406W 24.3% ± 1.14 43.0% ± 3.33 p < 0.005
  1. Values of cell death obtained when GFP/GSK3β (S9A) or GFP/tau transiently expressed were added together and compared to the actual values of cell death obtained when GFP/GSK3β (S9A)/tau were co-expressed. Synergistic cell death (bold entries) was observed when GSK3β (S9A) was co-expressed with 352PHP, R5H, K18, K18ΔK280, P301L, or R406W. Interestingly, cell death in the presence of G272V was not affected by the presence of GSK3β (S9A). N.S. = not significant.