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Table 1 Additive versus synergistic cell death induced by co-expression of AICD and tau

From: Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain

Tau % Cell death (Additive) = GFP/AICD + GFP/tau % Cell death ± SD (Actual) = GFP/AICD/tau p value
352tauWT 22.3% ± 1.46 24.6% ± 1.74 N.S.
441tauWT 20.9% ± 2.78 22.0% ± 2.36 N.S.
352tauPHP 21.7% ± 1.98 38.1% ± 4.35 p < 0.05
R5H 21.3% ± 2.49 42.9% ± 4.09 p < 0.01
K18 22.0% ± 4.24 39.0% ± 6.98 p < 0.05
K18ΔK280 42.5% ± 4.28 42.3% ± 4.61 N.S.
P301L 21.4% ± 2.97 30.2% ± 3.79 p < 0.05
G272V 21.9% ± 2.73 40.2% ± 1.40 p < 0.01
R406W 20.4% ± 3.93 31.7% ± 2.70 p < 0.05
  1. Values of cell death obtained when GFP/AICD or GFP/tau transiently expressed were added together and compared to the actual values of cell death obtained when GFP/AICD/tau were co-expressed. Synergistic cell death (bold entries) was observed when AICD was co-expressed with 352PHP, R5H, K18, P301L, G272V, or R406W. N.S. = not significant.