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Figure 5 | BMC Neuroscience

Figure 5

From: Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain

Figure 5

GSK3β (K85A) differentially influences cell death in the presence of AICD and tau. H4 cells were transiently transfected with equal amounts of plasmid DNA encoding GFP and different single tau variants in the absence of AICD (grey bars) or presence of AICD (black bars) or dominant negative GSK3β (K85A) and tau in the absence of AICD (check bar) or presence of AICD (striped bar). A. Tau variant 352WT, 441WT, or 352PHP. B. Tau variant G272V or P301L. C. Tau variant R5H or R406W. D. Tau variant K18 or K18ΔK280. GSK3β (K85A) significantly decreases cell death due to AICD and tau except in tau variants 352WT, 441WT, K18ΔK280 where there is no effect. *p < 0.05, **p < 0.01, ***p < 0.001. Error bars represent the standard deviation.

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