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Figure 7 | BMC Neuroscience

Figure 7

From: The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer’s disease

Figure 7

Confocal microscopy analysis of subcellular distribution of AIF in the cortex of Tg and non-Tg littermate mice shown at indicated ages. (A) Arrows point to the cells displaying the tAIF translocation to the nucleus which contrasts with the punctuate labelling in the cytoplasm reminiscent of mitochondrial localization. (B) The nuclear tranlocation of AIF was further analyzed by co-localization analysis of red and blue fluorescence corresponding to AIF and DAPI (used to stain the nuclei), respectively. Bar =10 μm.

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