AIF expression in cortical (A), hippocampal (B) and cerebellar (C) extracts from Tg mice and their age-matched non-Tg littermates at indicated ages. Both mitochondrial (62 kDa, white bars) and tAIF (57 kDa, black bars) forms of AIF were studied. Equal protein loading was confirmed by detection of β-actin. Results were expressed as the ratio of the values calculated for the transgenic over non-Tg mice. *P < 0.05; #P < 0.01; ##P < 0.001; ###P < 0.0001.