Figure 1
From: Microglial Cx3cr1knockout reduces prion disease incubation time in mice
Kaplan-Meier survival curves. Data are shown as % of surviving animals (y-axis) plotted against the number of days post-inoculation (x-axis). (A) Transmission of Chandler/RML prion strain to Cx3cr1-/- (n = 25) and Cx3cr1+/+ (WT, n = 24) controls (B) Transmission of ME7 prion strain to Cx3cr1-/- (n = 22) and Cx3cr1+/+ (WT, n = 24). (C) Transmission of MRC2 mouse adapted BSE prion strain to Cx3cr1-/- (n = 23) and Cx3cr1+/+ (WT, n = 21). A reduction in mean incubation time of 4%, 7%, and 7% was seen in A-C respectively. This reduction in survival was statistically significant for each transmission P = 0.004 (A) and P < 0.0001 (B and C), Kaplan-Meier log-rank survival test.