TY - JOUR AU - Heinonen, Ann-Marie AU - Rahman, Mahbubur AU - Dogbevia, Godwin AU - Jakobi, Hannah AU - Wölfl, Stefan AU - Sprengel, Rolf AU - Schwaninger, Markus PY - 2014 DA - 2014/03/11 TI - Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7 JO - BMC Neuroscience SP - 38 VL - 15 IS - 1 AB - Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functionally active BMPs, we expressed BMP7, BMP2 and the BMP inhibitor Noggin under the control of rAAV vectors in vivo. For visual control of rAAV-mediated BMP (v-BMP) expression we fused the secreted morphogenic polypeptides and the fluorescent reporter protein Venus via the ‘ribosomal skip’ promoting 2A peptide-bridge. SN - 1471-2202 UR - https://doi.org/10.1186/1471-2202-15-38 DO - 10.1186/1471-2202-15-38 ID - Heinonen2014 ER -