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Table 1 Bio-functions (gene ontology terms) of differentially expressed genes in Glud1 Tg vs. wt hippocampus across 5 ages

From: Gene expression patterns in the hippocampus during the development and aging of Glud1(Glutamate Dehydrogenase 1) transgenic and wild type mice

Term P value Key genes
Ras protein signal transduction 0.0016 Bcl6, Brap, Eps8l1, Hrasls, Nras, Ptplad1, Sdcbp
Metal ion transport (mostly for calcium and potassium) 0.0017 Atp1a2, Atp1b1, Atp2c1, Cacna1h, Cacnb4, Camk2g, Itpr2, Kcnab2, Kcnip2, Kcnip3, Kcnk1,,Kcnq2, Kcnt1, Sfxn1, Slc25a28, Slc38a9, Trpc4
Synaptic transmission 0.013 Atp1a2, Cacnb4, Capza2, Cplx3, Grid2, Grm4, Lin7c, Stx1b
Carboxylic acid transport 0.017 Cacnb4, Serinc1, Slc13a3, Slc1a1, Slc1a7, Slc38a9, Trpc4,
Actin cytoskeleton organization 0.027 Acta1, Arhgef2, Atp2c1, Bcl6, Capza2, Dbn1, Neurl2, Nras, Sorbs1
Stress-activated protein kinase signaling pathway (mostly MAPK and JNK cascades) 0.034 Brap, Cdc42se1, Errfi1, Fgf12, Fgf2, Gm8188, Map3k7, Myd88, Ptplad1
Mitochondrial envelop 0.05 Cds1, Cds2, Cox15, Cox4i2, Cox5a, Crls1, Cyb5b, Golph3, Nlrx1, Pi4kb, Ppp1cc, Sfxn1, Slc25a28, Tomm20