Table 1 Bio-functions (gene ontology terms) of differentially expressed genes in Glud1 Tg vs. wt hippocampus across 5 ages
Term | P value | Key genes |
|---|---|---|
Ras protein signal transduction | 0.0016 | Bcl6, Brap, Eps8l1, Hrasls, Nras, Ptplad1, Sdcbp |
Metal ion transport (mostly for calcium and potassium) | 0.0017 | Atp1a2, Atp1b1, Atp2c1, Cacna1h, Cacnb4, Camk2g, Itpr2, Kcnab2, Kcnip2, Kcnip3, Kcnk1,,Kcnq2, Kcnt1, Sfxn1, Slc25a28, Slc38a9, Trpc4 |
Synaptic transmission | 0.013 | Atp1a2, Cacnb4, Capza2, Cplx3, Grid2, Grm4, Lin7c, Stx1b |
Carboxylic acid transport | 0.017 | Cacnb4, Serinc1, Slc13a3, Slc1a1, Slc1a7, Slc38a9, Trpc4, |
Actin cytoskeleton organization | 0.027 | Acta1, Arhgef2, Atp2c1, Bcl6, Capza2, Dbn1, Neurl2, Nras, Sorbs1 |
Stress-activated protein kinase signaling pathway (mostly MAPK and JNK cascades) | 0.034 | Brap, Cdc42se1, Errfi1, Fgf12, Fgf2, Gm8188, Map3k7, Myd88, Ptplad1 |
Mitochondrial envelop | 0.05 | Cds1, Cds2, Cox15, Cox4i2, Cox5a, Crls1, Cyb5b, Golph3, Nlrx1, Pi4kb, Ppp1cc, Sfxn1, Slc25a28, Tomm20 |