TY - JOUR AU - Wang, Xinkun AU - Patel, Nilam D. AU - Hui, Dongwei AU - Pal, Ranu AU - Hafez, Mohamed M. AU - Sayed-Ahmed, Mohamed M. AU - Al-Yahya, Abdulaziz A. AU - Michaelis, Elias K. PY - 2014 DA - 2014/03/04 TI - Gene expression patterns in the hippocampus during the development and aging of Glud1(Glutamate Dehydrogenase 1) transgenic and wild type mice JO - BMC Neuroscience SP - 37 VL - 15 IS - 1 AB - Extraneuronal levels of the neurotransmitter glutamate in brain rise during aging. This is thought to lead to synaptic dysfunction and neuronal injury or death. To study the effects of glutamate hyperactivity in brain, we created transgenic (Tg) mice in which the gene for glutamate dehydrogenase (Glud1) is over-expressed in neurons and in which such overexpression leads to excess synaptic release of glutamate. In this study, we analyzed whole genome expression in the hippocampus, a region important for learning and memory, of 10 day to 20 month old Glud1 and wild type (wt) mice. SN - 1471-2202 UR - https://doi.org/10.1186/1471-2202-15-37 DO - 10.1186/1471-2202-15-37 ID - Wang2014 ER -