Expression pattern of mutant HTT and brain volumetric measurements in a transgenic HD monkey and control monkeys. (a) Quantitative measurement of mutant HTT transcript in controls and rHD1 peripheral blood at four time-points by quantitative PCR, (b) Western blot analysis of one of the control monkeys and rHD1 at various time points. Arrow indicates the expression of soluble form mutant HTT protein that was not observed in control monkey samples. (c) Longitudinal measurement of body weight. (d) Longitudinal measurement of head circumference. Longitudinal morphometric measurements of (e) hippocampus and (f) striatum at four time-points by MRI normalized with total brain volume.