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Table 3 Tail Length (μm), Tail DNA% and Tail Moments in PA-intoxicated, Co Q or melatonin supplemented compared to control- healthy rat pups

From: Selected biomarkers as predictive tools in testing efficacy of melatonin and coenzyme Q on propionic acid - induced neurotoxicity in rodent model of autism

Parameters

Groups

Min.

Max.

Mean ± S.D.

P value

Tail Length (μm)

Control

1.06

1.42

1.25 ± 0.16

0.001

PA

4.67

5.34

4.96 ± 0.28a

Melatonin-protected

3.17

4.33

3.56 ± 0.55a

Melatonin-treated

3.95

4.26

4.11 ± 0.13a

CoQ10-protected

2.87

3.05

2.94 ± 0.08a

CoQ10-treated

3.59

3.95

3.82 ± 0.16a

Tail DNA%

Control

1.22

1.62

1.40 ± 0.17

0.001

PA

4.51

5.15

4.85 ± 0.27a

Melatonin-protected

3.12

3.33

3.20 ± 0.09a

Melatonin-treated

3.52

4.26

3.95 ± 0.33a

CoQ10-protected

2.80

3.41

3.10 ± 0.25a

CoQ10-treated

3.16

3.75

3.55 ± 0.28a

Tail Moments (Units)

Control

1.42

2.15

1.76 ± 0.37

0.001

PA

21.96

25.78

24.07 ± 1.87a

Melatonin-protected

10.18

13.67

11.39 ± 1.57a

Melatonin-treated

15.00

17.79

16.20 ± 1.21a

CoQ10-protected

8.09

9.81

9.11 ± 0.76a

CoQ10-treated

11.33

14.83

13.58 ± 1.59a

  1. Table 3 describes the One-way ANOVA test between the Control, PPA, Melatonine + PA, PA + Melatonine, CO Q + PA and PA + CO Q groups in Tail Length (μm), Tail DNA% and Tail Moments (Units) groups and Dunnett test as multiple comparisons.
  2. aSignificant level between the studied groups compared to control when P < 0.05.