Table 2 Mean ± S.D and independent t-test for HSP-70, GABA, serotonin, dopamine, oxytocin, and Interferon μ inducible protein 16 (IFI-16) in neurointoxicated, melatonin protected and treated rat pups compared to healthy control

HSP70 (ng/ml)

Control

8

10.563 ± 0.370

PA

8

9.400 ± 0.490

0.001^a

Melatonin-protected group

8

10.043 ± 0.454

0.030^a

Melatonin-treated group

8

10.083 ± 0.445

0.048^a

GABA (ng/10 mg)

Control

8

109.100 ± 4.666

PA

8

67.183 ± 3.125

0.001^a

Melatonin-protected group

8

83.160 ± 4.668

0.01^a

Melatonin-treated group

8

75.144 ± 2.694

0.001^a

Serotonin (ng/ml)

Control

8

0.073 ± 0.017

PA

8

0.047 ± 0.011

0.004^a

Melatonin-protected group

8

0.101 ± 0.019

0.011^a

Melatonin-treated group

8

0.099 ± 0.019

0.016^a

Dopamine (ng/ml)

Control

8

136.250 ± 18.468

PA

8

106.875 ± 12.229

0.002^a

Melatonin-protected group

8

173.125 ± 29.873

0.010^a

Melatonin-treated group

8

164.375 ± 23.213

0.018^a

Oxytocin (Pg/ml)

Control

8

89.750 ± 4.464

PA

8

84.500 ± 4.751

0.039^a

Melatonin-protected group

8

97.750 ± 8.714

0.037^a

Melatonin-treated group

8

100.750 ± 6.409

0.001^a

Interferon μ inducible protein 16 (Pg/ml)

Control

8

833.750 ± 63.906

PA

8

768.750 ± 53.033

0.044^a

Melatonin-protected group

8

921.250 ± 71.801

0.022^a

Melatonin-treated group

8

922.500 ± 79.057

0.027^a