Table 4 Twenty KEGG and PANTHER pathways applied to the 500 hypermethylated genes in the thalamus

KEGG_PATHWAY

Long-term potentiation

9

5.270

2.58 × 10-4

0.033

KEGG_PATHWAY

MAPK signaling pathway

16

2.475

0.002

0.108

PANTHER_PATHWAY

Alzheimer disease-amyloid secretase pathway

9

3.872

0.002

0.147

KEGG_PATHWAY

Long-term depression

7

3.985

0.008

0.283

KEGG_PATHWAY

GnRH signaling pathway

8

3.380

0.009

0.250

KEGG_PATHWAY

Calcium signaling pathway

11

2.360

0.017

0.360

KEGG_PATHWAY

Vascular smooth muscle contraction

8

2.732

0.026

0.433

KEGG_PATHWAY

Wnt signaling pathway

9

2.476

0.028

0.405

KEGG_PATHWAY

Melanogenesis

7

2.869

0.034

0.428

PANTHER_PATHWAY

TGF-beta signaling pathway

10

2.080

0.046

0.876

KEGG_PATHWAY

Ubiquitin mediated proteolysis

8

2.411

0.046

0.496

PANTHER_PATHWAY

Endogenous_cannabinoid_signaling

4

4.832

0.047

0.757

PANTHER_PATHWAY

PDGF signaling pathway

11

1.930

0.052

0.698

KEGG_PATHWAY

Glycerophospholipid metabolism

5

3.059

0.078

0.654

PANTHER_PATHWAY

Endothelin signaling pathway

7

2.290

0.080

0.772

PANTHER_PATHWAY

Notch signaling pathway

5

2.963

0.084

0.727

PANTHER_PATHWAY

Metabotropic glutamate receptor group II pathway

5

2.908

0.088

0.691

KEGG_PATHWAY

Neurotrophin signaling pathway

7

2.207

0.095

0.692

PANTHER_PATHWAY

Ionotropic glutamate receptor pathway

5

2.804

0.098

0.682

KEGG_PATHWAY

N-Glycan biosynthesis

4

3.564

0.100

0.679