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Table 1 Summary of the significant pERK1, pERK2, P-p90RSK and c-Fos findings in mouse prefrontal cortex and striatum following aripiprazole and quetiapine treatment over 24 hours

From: Quetiapine and aripiprazole signal differently to ERK, p90RSK and c-Fos in mouse frontal cortex and striatum: role of the EGF receptor

APD

Brain region

Protein

20 min

60 min

240 min

480 min

24/24

Aripiprazole

Prefrontal cortex

pERK1

↓

↑

↓

-

-

pERK2

↓

↑

-

-

-

P-p90RSK

-

-

-

-

-

c-Fos

-

↑

-

-

-

Striatum

pERK1

-

-

-

-

-

pERK2

-

-

-

-

-

P-p90RSK

-

-

-

-

-

c-Fos

↑

↑

-

-

-

Quetiapine

Prefrontal cortex

pERK1

-

-

-

-

-

pERK2

-

-

-

-

-

P-p90RSK

↓

-

-

-

-

c-Fos

-

-

↑

-

-

Striatum

pERK1

-

-

↑

-

-

pERK2

-

-

-

-

-

P-p90RSK

↓

↓

-

-

-

  

c-Fos

-

-

↑

-

-

  1. ↓ = significantly decreased protein phosphorylation.
  2. ↑ = significantly increased protein phosphorylation.
  3. - = no significant change.
  4. APD = antipsychotic drug, min = minutes.
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BMC Neuroscience

ISSN: 1471-2202

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