Figure 2

Effect of quetiapine on ERK phosphorylation in C57Bl/6 mouse striatum. Representative blots (A) indicate immunoreactive bands of phosphorylated ERK1 and phosphorylated ERK2 (upper panel) and total ERK1 and total ERK2 (lower panel) levels following quetiapine (5 mg/kg) treatment and correspond with the bar graphs below. (B) Quetiapine treatment over a 24 hr period - pERK1/ERK1. (C) Quetiapine treatment over a 24 hr period - pERK2/ERK2. At each time point treated samples were expressed relative to vehicle control standardized to 100 percent. Data represent the mean ± SEM of at least four mice per experimental group. **p < 0.01, statistical differences between tissue in the absence (vehicle) and presence of quetiapine are indicated.