Figure 1

Effect of aripiprazole on ERK phosphorylation in C57Bl/6 mouse prefrontal cortex. Representative blots (A) indicate immunoreactive bands of phosphorylated ERK1 and phosphorylated ERK2 (upper panel) and total ERK1 and total ERK2 (lower panel) levels following aripiprazole (1 mg/kg) treatment and correspond with the bar graphs below. (B) Aripiprazole treatment over a 24 hr period - pERK1/ERK1. (C) Aripiprazole treatment over a 24 hr period - pERK2/ERK2. At each time point treated samples were expressed relative to vehicle control standardized to 100 percent. Data represent the mean ± SEM of at least four mice per experimental group. *p < 0.05; **p < 0.01, statistical differences between tissue in the absence (vehicle) and presence of aripiprazole are indicated.