Figure 5

Modulation of network dynamics by thalamic inputs in vitro . A, Typical traces of seizure-like activity with and without medial thalamic inputs. The duration of epileptic activity was prolonged after cutting the thalamic inputs. B-C, Comparison of ISI, amplitude, duration, and average discharge in a bar chart. Notice that the average discharge significantly decreased after cutting the thalamic inputs. D, Color map of isopotential, 2D-CSD, and correlation coefficient with and without medial thalamic inputs. E-G, Bar chart of 2D-CSD in the ictal/tonic and clonic phases of seizure activity. Removal of the thalamic inputs increased the correlation coefficient compared with the control group. H-I, Power spectrum of FFT during seizure activity and statistical bar chart. The power of the low frequency and delta bands significantly decreased after cutting the thalamic inputs. J, Coherence of each frequency band in the vertical and horizontal directions. The coherence in the horizontal direction decreased more after cutting the thalamic inputs. K-M, Avalanche size and lifetime shown on a log-log scale. The statistical bar chart indicates that the avalanche size significantly increased in the group with cut thalamic inputs. *p < 0.01.