Figure 4

Neuronal avalanche in a suppressed network. A, Typical traces before and after application of the gap junction blocker Oct, which changed seizure-like activity into a constant, repeated, short-duration firing pattern. B-C, Comparison of ISI, amplitude, duration, and average discharge in a bar chart. Notice that the average discharge significantly decreased with a suppression of network dynamics. D, Color map of isopotential, 2D-CSD, and correlation coefficient before and after Oct application. E-G, 2D-CSD in the ictal/tonic and clonic phases of seizure activity and statistical bar chart. The application of Oct increased the correlation coefficient compared with the control group. H-I, Power spectrum of FFT and statistical bar chart. The power of the delta and alpha bands decreased in the Oct group. J, Coherence of each frequency band in the vertical and horizontal directions. The coherence in both the horizontal and vertical directions increased after Oct application. K-M, Avalanche size and lifetime distribution on a log-log scale. The statistical bar chart indicates that the avalanche size significantly decreased after the application of Oct. *p < 0.01.