Figure 8

The biophysical properties of the chimeric Eag channels. Comparison of the voltage-dependent gating properties of the rEag1 (A) or rEag2 (B) chimeras with their wild-type (WT) counterparts. Steady-state voltage dependence (activation curve) is illustrated as the fraction of open channels (Po) against the corresponding membrane potential. Activation time constants at indicated potentials were obtained from single exponential fits to the late rising phase of Eag K⁺ currents. Deactivation time constants were derived from single exponential fits to the decay phase of Eag K⁺ currents at the indicated tail potential in response to a +40 mV test pulse. All values are presented as mean ± SEM. Data were collected and analyzed as described previously [18].