Skip to main content

Table 2 Multiple regression analysis

From: Impact of methodology on estrogens’ effects on cerebral ischemia in rats: an updated meta-analysis

Variable (reference category) Variable categories Regression coefficient 0.95 Confidence interval for regression coefficient p-value
Lower bound Upper bound
Constant/baseline – showing the effect of the reference categories NA 93.4 76.7 110.1  
Estrogen administration mode (Slow-release pellets) Injections -31.9 -48.5 -15.2 0.000
Silastic capsules -38.2 -54.9 -21.6 0.000
Per oral -59.3 -129.3 10.7 0.096
Type of middle cerebral artery occlusion procedure (Intraluminal filament) Direct, mechanical 33.2 18.8 47.6 0.000
Embolic -42.0 -90.8 6.7 0.091
Photothrombotic 20.6 -53.1 94.2 0.581
Endothelin injection 2.3 -31.2 35.9 0.891
Laser-doppler flowmetry during surgery (No) [Yes] -15.3 -29.4 -1.2 0.034
Edema correction (No edema correction used) Correcting for edema in infarct -21.8 -54.2 10.6 0.184
Correcting for edema in entire hemisphere -23.1 -39.6 -6.7 0.006
Length of time between initiation of estrogen administration and induction of the ischemic damage Continuous; hours 0.025 0.011 0.040 0.001
  1. Variables excluded in preceding multiple regression analysis (with backward exclusion) due to too low explanatory value: Strain, Sex, Elderly rats, Washout (Length of time between ovariectomy and estrogen administration), Occlusion duration, Length of time between ischemia and evaluation of damage.