Table 2 Multiple regression analysis
From: Impact of methodology on estrogens’ effects on cerebral ischemia in rats: an updated meta-analysis
Variable (reference category) | Variable categories | Regression coefficient | 0.95 Confidence interval for regression coefficient | p-value | |
|---|---|---|---|---|---|
Lower bound | Upper bound | ||||
Constant/baseline – showing the effect of the reference categories | NA | 93.4 | 76.7 | 110.1 |  |
Estrogen administration mode (Slow-release pellets) | Injections | -31.9 | -48.5 | -15.2 | 0.000 |
Silastic capsules | -38.2 | -54.9 | -21.6 | 0.000 | |
Per oral | -59.3 | -129.3 | 10.7 | 0.096 | |
Type of middle cerebral artery occlusion procedure (Intraluminal filament) | Direct, mechanical | 33.2 | 18.8 | 47.6 | 0.000 |
Embolic | -42.0 | -90.8 | 6.7 | 0.091 | |
Photothrombotic | 20.6 | -53.1 | 94.2 | 0.581 | |
Endothelin injection | 2.3 | -31.2 | 35.9 | 0.891 | |
Laser-doppler flowmetry during surgery (No) | [Yes] | -15.3 | -29.4 | -1.2 | 0.034 |
Edema correction (No edema correction used) | Correcting for edema in infarct | -21.8 | -54.2 | 10.6 | 0.184 |
Correcting for edema in entire hemisphere | -23.1 | -39.6 | -6.7 | 0.006 | |
Length of time between initiation of estrogen administration and induction of the ischemic damage | Continuous; hours | 0.025 | 0.011 | 0.040 | 0.001 |