Figure 2

After controlling for confounding factors, it remained clear that slow-release pellets rendered significantly higher EC-ratios than the injection and silastic capsule regimens did (p < 0.001). The black diamonds mark the mean EC-ratio with 95% confidence interval for each of the three administration modes. Of note, the slow-release pellet diamond reaches over the 100% EC-ratio line, demonstrating the pellets’ potential for harm as well as protection. EC-ratio = infarct size in estrogen treated group divided by infarct size in control group.