Functional associations among G protein-coupled neurotransmitter receptors in the human brain

Janušonis, Skirmantas

doi:10.1186/1471-2202-15-16

BMC Neuroscience

Table 2 The five strongest positive and negative correlations of each receptor with other receptors, calculated using 169 brain regions

From: Functional associations among G protein-coupled neurotransmitter receptors in the human brain

1) mGluR1		2) mGluR2		3) mGluR3		4) mGluR4		5) mGluR5		6) mGluR6
50	0.80	72	0.65	90	0.72	57	0.93	72	0.82	88	0.63
4	0.74	18	0.64	43	0.62	50	0.76	39	0.81	4	0.63
57	0.71	43	0.63	23	0.51	1	0.74	65	0.80	57	0.60
46	0.65	97	0.60	22	0.50	46	0.68	7	0.79	50	0.54
98	0.63	23	0.58	93	0.49	47	0.66	43	0.76	47	0.53
68	−0.51	69	−0.33	6	−0.22	62	−0.64	50	−0.32	42	−0.34
52	−0.53	80	−0.34	59	−0.26	39	−0.64	46	−0.39	39	−0.35
75	−0.54	46	−0.35	69	−0.27	76	−0.68	47	−0.49	32	−0.39
40	−0.55	57	−0.55	57	−0.31	30	−0.72	57	−0.57	22	−0.42
32	−0.63	4	−0.56	4	−0.32	42	−0.76	4	−0.58	23	−0.50
7) mGluR7		8) mGluR8		9) GABA1		10) GABA2		11) D1		12) D2
5	0.79	15	0.57	10	0.63	9	0.63	65	0.74	40	0.71
72	0.76	74	0.52	92	0.57	49	0.58	21	0.74	35	0.69
62	0.65	53	0.47	1	0.49	17	0.58	22	0.71	68	0.67
65	0.65	40	0.47	98	0.49	39	0.56	43	0.70	75	0.66
42	0.64	38	0.46	50	0.47	34	0.56	33	0.69	100	0.66
50	−0.40	50	−0.34	8	−0.25	54	−0.27	4	−0.31	50	−0.49
57	−0.50	4	−0.35	32	−0.25	27	−0.28	47	−0.32	77	−0.50
46	−0.50	98	−0.39	41	−0.28	12	−0.31	69	−0.32	46	−0.60
4	−0.52	1	−0.39	14	−0.31	83	−0.32	57	−0.34	85	−0.67
47	−0.59	57	−0.43	53	−0.31	32	−0.41	54	−0.35	49	−0.70
13) D3		14) D4		15) D5		16) α1A		17) α1B		18) α1D
91	0.68	51	0.40	72	0.66	84	0.52	56	0.63	72	0.76
27	0.65	70	0.22	75	0.63	63	0.38	39	0.63	36	0.72
33	0.64	98	0.18	68	0.62	7	0.31	30	0.63	5	0.71
21	0.63	97	0.17	52	0.61	94	0.26	42	0.59	2	0.64
12	0.62	46	0.17	82	0.60	79	0.26	55	0.59	39	0.64
34	−0.19	7	−0.29	1	−0.47	39	−0.14	35	−0.29	47	−0.39
10	−0.22	9	−0.31	46	−0.49	74	−0.16	57	−0.30	80	−0.43
49	−0.24	94	−0.31	50	−0.50	90	−0.18	54	−0.30	46	−0.45
46	−0.27	68	−0.34	57	−0.60	20	−0.22	64	−0.30	4	−0.53
50	−0.30	60	−0.35	4	−0.60	44	−0.31	4	−0.35	57	−0.54
19) α2A		20) α2B		21) α2C		22) β1		23) β2		24) β3
73	0.63	91	0.50	11	0.74	29	0.74	93	0.68	78	0.69
81	0.50	13	0.43	33	0.67	11	0.71	100	0.62	79	0.67
83	0.49	12	0.42	91	0.65	39	0.71	68	0.60	100	0.63
7	0.48	35	0.40	27	0.65	37	0.69	97	0.59	82	0.61
52	0.47	43	0.33	13	0.63	56	0.69	40	0.58	89	0.57
91	−0.27	80	−0.24	57	−0.25	47	−0.44	6	−0.50	77	−0.19
4	−0.27	49	−0.27	47	−0.26	54	−0.44	85	−0.53	98	−0.20
47	−0.29	25	−0.31	1	−0.29	69	−0.45	34	−0.56	56	−0.22
50	−0.30	34	−0.32	46	−0.32	57	−0.50	4	−0.57	85	−0.30
46	−0.33	77	−0.33	50	−0.34	4	−0.53	57	−0.59	49	−0.31
25) 5-HT1A		26) 5-HT1B		27) 5-HT1D		28) 5-HT1E		29) 5-HT1F		30) 5-HT2A
39	0.66	40	0.67	21	0.65	65	0.62	56	0.87	42	0.84
62	0.64	100	0.61	13	0.65	5	0.58	30	0.83	29	0.83
42	0.64	82	0.61	94	0.63	62	0.56	86	0.80	39	0.80
30	0.64	78	0.61	40	0.60	39	0.55	55	0.78	55	0.80
7	0.62	35	0.60	33	0.59	43	0.53	39	0.78	56	0.76
20	−0.31	1	−0.30	49	−0.30	14	−0.17	66	−0.35	54	−0.40
47	−0.35	98	−0.32	98	−0.32	95	−0.19	69	−0.39	1	−0.43
54	−0.35	49	−0.38	1	−0.32	57	−0.24	57	−0.46	47	−0.54
57	−0.49	85	−0.39	46	−0.44	4	−0.25	54	−0.48	57	−0.71
4	−0.51	46	−0.46	50	−0.46	54	−0.30	4	−0.49	4	−0.72
31) 5-HT2B		32) 5-HT2C		33) 5-HT4		34) 5-HT5A		35) 5-HT6		36) 5-HT7
61	0.54	75	0.70	65	0.79	85	0.63	12	0.69	18	0.72
35	0.54	68	0.64	5	0.71	49	0.63	40	0.65	72	0.72
45	0.53	94	0.63	11	0.69	77	0.59	100	0.63	38	0.65
58	0.51	12	0.61	21	0.67	1	0.56	26	0.60	7	0.60
88	0.48	40	0.60	62	0.67	10	0.56	27	0.56	68	0.59
62	−0.16	85	−0.61	46	−0.45	40	−0.44	46	−0.33	57	−0.46
17	−0.18	1	−0.63	57	−0.48	78	−0.47	77	−0.35	80	−0.47
49	−0.21	98	−0.64	50	−0.49	95	−0.47	56	−0.39	49	−0.49
85	−0.21	46	−0.70	4	−0.50	100	−0.54	85	−0.50	85	−0.61
56	−0.24	50	−0.76	47	−0.50	23	−0.56	49	−0.54	46	−0.62
37) M1		38) M2		39) M3		40) M4		41) M5		42) H1
43	0.73	36	0.65	5	0.81	12	0.71	75	0.80	30	0.84
39	0.70	72	0.63	30	0.80	100	0.70	53	0.65	39	0.80
22	0.69	15	0.59	42	0.80	68	0.69	68	0.63	62	0.77
29	0.67	26	0.57	43	0.78	75	0.68	82	0.61	55	0.74
56	0.65	53	0.53	29	0.78	26	0.67	83	0.59	5	0.73
59	−0.36	46	−0.45	69	−0.40	49	−0.53	1	−0.47	50	−0.43
44	−0.37	99	−0.45	54	−0.44	1	−0.55	46	−0.52	1	−0.45
57	−0.45	80	−0.46	47	−0.44	85	−0.58	50	−0.53	47	−0.54
4	−0.45	77	−0.50	57	−0.62	50	−0.58	49	−0.60	57	−0.72
69	−0.55	85	−0.53	4	−0.64	46	−0.64	85	−0.69	4	−0.76
43) H2		44) H3		45) H4		46) B1		47) B2		48) CCK1
39	0.78	69	0.42	58	0.56	50	0.78	46	0.76	67	0.67
5	0.76	12	0.39	89	0.54	47	0.76	4	0.66	75	0.53
72	0.73	9	0.39	35	0.53	85	0.70	57	0.63	41	0.52
37	0.73	4	0.36	31	0.53	4	0.68	50	0.61	53	0.49
11	0.70	20	0.29	61	0.52	57	0.66	6	0.53	58	0.46
80	−0.30	16	−0.31	86	−0.19	36	−0.62	62	−0.50	46	−0.26
47	−0.35	29	−0.32	98	−0.24	40	−0.64	52	−0.52	50	−0.33
69	−0.42	55	−0.33	56	−0.24	75	−0.69	30	−0.54	85	−0.34
4	−0.50	37	−0.37	85	−0.30	68	−0.69	42	−0.54	49	−0.35
57	−0.50	97	−0.38	49	−0.31	32	−0.70	7	−0.59	98	−0.38
49) CCK2		50) CRF1		51) CRF2		52) Gal1		53) Gal2		54) Gal3
85	0.93	1	0.80	14	0.40	15	0.61	75	0.75	64	0.62
56	0.78	46	0.78	85	0.39	68	0.61	73	0.67	78	0.56
77	0.71	4	0.76	86	0.34	60	0.59	41	0.65	100	0.56
98	0.67	57	0.74	49	0.31	73	0.57	83	0.64	24	0.55
46	0.63	98	0.71	22	0.30	32	0.57	82	0.63	89	0.55
41	−0.60	40	−0.58	94	−0.29	57	−0.52	50	−0.48	39	−0.44
75	−0.67	94	−0.61	36	−0.29	1	−0.53	46	−0.49	85	−0.44
100	−0.69	68	−0.66	75	−0.33	50	−0.56	49	−0.58	29	−0.48
12	−0.70	75	−0.68	41	−0.34	46	−0.56	98	−0.59	49	−0.54
66	−0.71	32	−0.76	68	−0.41	4	−0.58	85	−0.63	56	−0.63
55) MCH1		56) MCH2		57) MC1		58) MC2		59) MC3		60) MC4
30	0.80	29	0.87	4	0.93	45	0.56	60	0.34	52	0.59
29	0.78	49	0.78	50	0.74	35	0.54	69	0.29	32	0.56
42	0.74	30	0.76	1	0.71	61	0.53	44	0.27	68	0.56
39	0.72	39	0.75	46	0.66	31	0.51	41	0.26	75	0.55
56	0.71	86	0.74	47	0.63	100	0.47	84	0.24	15	0.47
47	−0.29	12	−0.43	15	−0.60	86	−0.18	2	−0.24	98	−0.38
44	−0.33	100	−0.44	39	−0.62	56	−0.21	23	−0.24	1	−0.40
69	−0.36	64	−0.46	76	−0.65	85	−0.25	90	−0.25	47	−0.44
57	−0.50	66	−0.55	30	−0.71	98	−0.25	3	−0.26	50	−0.45
4	−0.52	54	−0.63	42	−0.72	49	−0.25	37	−0.36	46	−0.54
61) MC5		62) Y1		63) Y2		64) Y4		65) Y5		66) Y6
88	0.55	65	0.93	7	0.59	54	0.62	62	0.93	100	0.66
31	0.54	42	0.77	42	0.53	100	0.59	5	0.80	75	0.63
58	0.53	5	0.73	62	0.51	96	0.57	33	0.79	12	0.61
45	0.52	39	0.70	65	0.50	89	0.57	11	0.74	82	0.58
6	0.51	33	0.67	30	0.45	24	0.55	39	0.73	36	0.57
11	−0.12	46	−0.39	46	−0.34	85	−0.33	46	−0.38	46	−0.45
90	−0.14	50	−0.43	57	−0.40	30	−0.36	50	−0.44	77	−0.51
98	−0.14	47	−0.50	50	−0.41	49	−0.39	47	−0.49	56	−0.55
91	−0.14	57	−0.57	47	−0.47	86	−0.40	57	−0.54	85	−0.70
22	−0.16	4	−0.64	4	−0.51	56	−0.46	4	−0.59	49	−0.71
67) NT1		68) NT2		69) μ		70) δ		71) κ		72) ORL-1
48	0.67	75	0.81	4	0.49	43	0.61	72	0.52	5	0.82
75	0.65	94	0.77	57	0.44	22	0.60	62	0.51	7	0.76
68	0.64	40	0.69	44	0.42	37	0.59	65	0.48	18	0.76
82	0.57	12	0.67	1	0.39	56	0.58	5	0.46	39	0.74
41	0.56	32	0.64	9	0.39	90	0.57	17	0.45	43	0.73
85	−0.40	57	−0.56	42	−0.40	66	−0.25	50	−0.13	80	−0.40
50	−0.46	4	−0.57	39	−0.40	83	−0.27	46	−0.18	47	−0.47
46	−0.48	85	−0.61	43	−0.42	53	−0.28	4	−0.18	46	−0.53
57	−0.48	50	−0.66	22	−0.45	4	−0.28	57	−0.19	57	−0.58
4	−0.49	46	−0.69	37	−0.55	69	−0.39	14	−0.19	4	−0.60
73) OX1		74) OX2		75) OT		76) SST1		77) SST2		78) SST3
83	0.69	53	0.54	68	0.81	42	0.72	99	0.77	100	0.78
53	0.67	41	0.53	41	0.80	62	0.66	49	0.71	82	0.73
75	0.64	8	0.52	53	0.75	39	0.64	85	0.70	24	0.69
19	0.63	73	0.50	82	0.72	30	0.62	34	0.59	79	0.66
41	0.57	38	0.48	32	0.70	65	0.61	80	0.57	40	0.66
1	−0.39	92	−0.35	98	−0.59	1	−0.41	12	−0.50	34	−0.47
85	−0.45	50	−0.36	49	−0.67	46	−0.43	93	−0.50	77	−0.49
46	−0.48	77	−0.39	50	−0.68	50	−0.46	66	−0.51	46	−0.49
50	−0.51	98	−0.41	46	−0.69	57	−0.65	95	−0.53	49	−0.53
98	−0.53	85	−0.43	85	−0.73	4	−0.68	100	−0.54	85	−0.59
79) SST4		80) SST5		81) NK1		82) NK2		83) NK3		84) TRHR
24	0.67	50	0.61	40	0.66	100	0.77	73	0.69	16	0.52
78	0.66	85	0.59	27	0.59	78	0.73	53	0.64	67	0.51
100	0.60	46	0.58	94	0.57	75	0.72	75	0.64	32	0.51
82	0.58	77	0.57	12	0.57	40	0.65	82	0.64	75	0.51
2	0.54	4	0.56	82	0.57	83	0.64	41	0.59	83	0.50
77	−0.17	18	−0.43	4	−0.36	4	−0.42	49	−0.54	49	−0.38
57	−0.18	23	−0.44	57	−0.36	50	−0.44	46	−0.54	50	−0.38
4	−0.20	38	−0.46	1	−0.40	49	−0.54	50	−0.55	85	−0.38
49	−0.25	75	−0.46	50	−0.46	46	−0.59	85	−0.57	98	−0.40
85	−0.29	36	−0.47	46	−0.49	85	−0.63	98	−0.58	46	−0.43
85) VPAC1		86) VPAC2		87) V1a		88) V1b		89) V2		90) A1
49	0.93	29	0.80	76	0.46	6	0.63	100	0.65	3	0.72
77	0.70	56	0.74	19	0.44	61	0.55	78	0.63	98	0.59
46	0.70	30	0.67	7	0.40	31	0.48	24	0.57	70	0.57
98	0.68	55	0.62	32	0.40	58	0.43	64	0.57	43	0.53
50	0.65	22	0.62	52	0.39	96	0.38	54	0.55	39	0.53
12	−0.67	66	−0.35	50	−0.32	30	−0.22	98	−0.34	84	−0.34
41	−0.69	4	−0.36	46	−0.33	39	−0.23	77	−0.37	53	−0.34
66	−0.70	69	−0.38	57	−0.36	62	−0.25	56	−0.39	73	−0.34
75	−0.73	64	−0.40	4	−0.36	22	−0.26	85	−0.47	32	−0.36
100	−0.74	54	−0.42	47	−0.39	23	−0.26	49	−0.50	83	−0.39
91) A2A		92) A2B		93) A3		94) P2Y1		95) P2Y2		96) P2Y4
13	0.68	9	0.57	23	0.68	68	0.77	100	0.58	64	0.57
21	0.65	99	0.51	100	0.59	32	0.63	23	0.55	24	0.52
11	0.55	22	0.46	41	0.57	27	0.63	40	0.54	79	0.47
27	0.53	56	0.45	97	0.56	21	0.58	12	0.49	89	0.44
12	0.53	49	0.44	78	0.55	81	0.57	38	0.49	54	0.43
10	−0.25	53	−0.28	99	−0.37	57	−0.45	99	−0.46	86	−0.17
55	−0.25	100	−0.31	34	−0.43	4	−0.46	34	−0.47	62	−0.18
87	−0.25	66	−0.34	49	−0.48	1	−0.48	77	−0.53	42	−0.18
19	−0.27	54	−0.34	77	−0.50	46	−0.55	49	−0.54	30	−0.19
76	−0.29	74	−0.35	85	−0.53	50	−0.61	85	−0.54	87	−0.23
97) P2Y6		98) P2Y11		99) CB1		100) CB2
2	0.60	50	0.71	77	0.77	78	0.78
23	0.59	85	0.68	49	0.54	82	0.77
93	0.56	49	0.67	85	0.53	40	0.70
15	0.49	46	0.64	92	0.51	12	0.66
3	0.48	1	0.63	80	0.46	66	0.66
1	−0.31	73	−0.53	93	−0.37	46	−0.49
80	−0.36	83	−0.58	23	−0.38	34	−0.54
44	−0.38	75	−0.59	100	−0.38	77	−0.54
57	−0.45	53	−0.59	38	−0.45	49	−0.69
4	−0.50	32	−0.64	95	−0.46	85	−0.74

The receptor numbers (Table 1) are given in the left column and the correlations in the right column (e.g., mGluR1 has the strongest positive correlation with CRF1 (0.80)). Correlations with an absolute value of less than 0.34 are not significant after the Bonferroni correction (at α = 0.05) and should be interpreted with caution. The actual correlations may be somewhat stronger due the imperfect reliability of the expression data (the statistical “attenuation” phenomenon).
For compactness, the following abbreviations were used: GABA1 = GABABR1, GABA2 = GABABR2.

Back to article page

ISSN: 1471-2202

Contact us

General enquiries: journalsubmissions@springernature.com