Functional associations among G protein-coupled neurotransmitter receptors in the human brain

Janušonis, Skirmantas

doi:10.1186/1471-2202-15-16

BMC Neuroscience

Table 1 The analyzed G protein-coupled receptors

From: Functional associations among G protein-coupled neurotransmitter receptors in the human brain

Number	Neurotransmitter	Receptor	Gene	Coupling	Median inter-subject correlation
1	Glutamate	mGluR1	GRM1	Gq	0.91
2	Glutamate	mGluR2	GRM2	Gi	0.37
3	Glutamate	mGluR3	GRM3	Gi	0.82
4	Glutamate	mGluR4	GRM4	Gi	0.94
5	Glutamate	mGluR5	GRM5	Gq	0.92
6	Glutamate	mGluR6	GRM6	Gi	0.12
7	Glutamate	mGluR7	GRM7	Gi	0.89
8	Glutamate	mGluR8	GRM8	Gi	0.45
9	GABA	GABABR1	GABBR1	Gi	0.78
10	GABA	GABABR2	GABBR2	Gi	0.89
11	Dopamine	D1	DRD1	Gs	0.91
12	Dopamine	D2	DRD2	Gi	0.89
13	Dopamine	D3	DRD3	Gi	0.69
14	Dopamine	D4	DRD4	Gi	0.03
15	Dopamine	D5	DRD5	Gs	0.83
16	Adrenergic	α1A	ADRA1A	Gq	0.76
17	Adrenergic	α1B	ADRA1B	Gq	0.87
18	Adrenergic	α1D	ADRA1D	Gq	0.79
19	Adrenergic	α2A	ADRA2A	Gi	0.62
20	Adrenergic	α2B	ADRA2B	Gi	0.31
21	Adrenergic	α2C	ADRA2C	Gi	0.64
22	Adrenergic	β1	ADRB1	Gs	0.59
23	Adrenergic	β2	ADRB2	Gs	0.67
24	Adrenergic	β3	ADRB3	Gs/Gi	0.15
25	Serotonin	5-HT1A	HTR1A	Gi	0.86
26	Serotonin	5-HT1B	HTR1B	Gi	0.38
27	Serotonin	5-HT1D	HTR1D	Gi	0.79
28	Serotonin	5-HT1E	HTR1E	Gi	0.82
29	Serotonin	5-HT1F	HTR1F	Gi	0.90
30	Serotonin	5-HT2A	HTR2A	Gq	0.95
31	Serotonin	5-HT2B	HTR2B	Gq	0.12
32	Serotonin	5-HT2C	HTR2C	Gq	0.92
33	Serotonin	5-HT4	HTR4	Gs	0.89
34	Serotonin	5-HT5A	HTR5A	Gs	0.89
35	Serotonin	5-HT6	HTR6	Gs	0.21
36	Serotonin	5-HT7	HTR7	Gs	0.89
37	Cholinergic	M1	CHRM1	Gq	0.53
38	Cholinergic	M2	CHRM2	Gi	0.91
39	Cholinergic	M3	CHRM3	Gq	0.96
40	Cholinergic	M4	CHRM4	Gi	0.53
41	Cholinergic	M5	CHRM5	Gq	0.63
42	Histamine	H1	HRH1	Gq	0.82
43	Histamine	H2	HRH2	Gs	0.69
44	Histamine	H3	HRH3	Gi	0.66
45	Histamine	H4	HRH4	Gi	0.09
46	Bradykinin	B1	BDKRB1	Gq	0.69
47	Bradykinin	B2	BDKRB2	Gq	0.61
48	Cholecystokinin	CCK1	CCKAR	Gq	0.46
49	Cholecystokinin	CCK2	CCKBR	Gq	0.94
50	CRH	CRF1	CRHR1	Gs	0.65
51	CRH	CRF2	CRHR2	Gs	0.35
52	Galanin	Gal1	GALR1	Gi	0.74
53	Galanin	Gal2	GALR2	Gi/Gq	0.54
54	Galanin	Gal3	GALR3	Gi	0.08
55	MCH	MCH1	MCHR1	Gi	0.70
56	MCH	MCH2	MCHR2	Gq	0.93
57	MSH	MC1	MC1R	Gs	0.73
58	MSH	MC2	MC2R	Gs	0.10
59	MSH	MC3	MC3R	Gs	0.40
60	MSH	MC4	MC4R	Gs	0.49
61	MSH	MC5	MC5R	Gs	0.04
62	NPY	Y1	NPY1R	Gi	0.91
63	NPY	Y2	NPY2R	Gi	0.74
64	NPY	Y4	PPYR1	Gi	0.18
65	NPY	Y5	NPY5R	Gi	0.86
66	NPY	Y6	NPY6R	Gi	0.36
67	Neurotensin	NT1	NTSR1	Gq	0.48
68	Neurotensin	NT2	NTSR2	Gq	0.81
69	Opioid	μ	OPRM1	Gi	0.84
70	Opioid	δ	OPRD1	Gi	0.25
71	Opioid	κ	OPRK1	Gi	0.67
72	Nociceptin	ORL-1	OPRL1	Gi	0.81
73	Orexin	OX1	HCRTR1	Gq	0.82
74	Orexin	OX2	HCRTR1	Gi	0.64
75	Oxytocin	OT	OXTR	Gq	0.75
76	Somatostatin	SST1	SSTR1	Gi	0.81
77	Somatostatin	SST2	SSTR2	Gi	0.91
78	Somatostatin	SST3	SSTR3	Gi	0.28
79	Somatostatin	SST4	SSTR4	Gi	0.07
80	Somatostatin	SST5	SSTR5	Gi	0.16
81	Tachykinin	NK1	TACR1	Gq	0.55
82	Tachykinin	NK2	TACR2	Gq	0.34
83	Tachykinin	NK3	TACR3	Gq	0.81
84	TRH	TRHR	TRHR	Gq	0.79
85	VIP	VPAC1	VIPR1	Gs	0.86
86	VIP	VPAC2	VIPR2	Gs	0.77
87	Vasopressin	V1a	AVPR1A	Gq	0.34
88	Vasopressin	V1b	AVPR1B	Gq	0.04
89	Vasopressin	V2	AVPR2	Gs	0.16
90	Adenosine	A1	ADORA1	Gi	0.66
91	Adenosine	A2A	ADORA2A	Gs	0.87
92	Adenosine	A2B	ADORA2B	Gs	0.57
93	Adenosine	A3	ADORA3	Gi	0.37
94	Purine	P2Y1	P2RY1	Gq	0.72
95	Purine	P2Y2	P2RY2	Gi/Gq	0.37
96	Purine	P2Y4	P2RY4	Gi/Gq	0.00
97	Purine	P2Y6	P2RY6	Gq	0.32
98	Purine	P2Y11	P2RY11	Gq	0.34
99	Cannabinoid	CB1	CNR1	Gi	0.90
100	Cannabinoid	CB2	CNR2	Gi	0.46

The inter-subject correlations were obtained from 6 subjects (15 cross-correlations).

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