Brain region | Saline (n = 6) | Quinpirole (n = 7) |
---|---|---|
Telencephalon | Â | Â |
Prefrontal cortex layer I | 3.42 ± 0.87 | 3.00 ± 0.73 |
Prefrontal cortex layer IV | 3.76 ± 0.98 | 3.66 ± 1.21 |
Primary olfactory cortex | 3.28 ± 0.85 | 3.77 ± 1.76 |
Frontal cortex (10) | Â | Â |
Layer I | 3.13 ± 0.79 | 3.88 ± 1.54 |
Layer IV | 3.51 ± 1.00 | 4.26 ± 1.67 |
Frontal cortex (8) | Â | Â |
Layer I | 3.38 ± 0.91 | 3.76 ± 1.77 |
Layer IV | 3.66 ± 1.02 | 4.13 ± 1.91 |
Pyriform cortex | 3.29 ± 0.60 | 3.12 ± 0.92 |
Anterior cingulate cortex | 4.18 ± 0.93 | 5.06 ± 2.80 |
Motor cortex | Â | Â |
Layer I | 3.35 ± 0.71 | 3.60 ± 1.39 |
Layer II – III | 3.72 ± 0.88 | 4.39 ± 1.74 |
Layer IV | 4.00 ± 0.92 | 4.42 ± 1.59 |
Layer V | 3.35 ± 0.79 | 3.64 ± 1.35 |
Layer VI | 3.25 ± 0.61 | 3.50 ± 1.29 |
Somatosensory cortex | Â | Â |
Layer I | 3.61 ± 0.83 | 4.01 ± 1.57 |
Layer II–III | 3.97 ± 0.88 | 4.68 ± 1.92 |
Layer IV | 4.20 ± 1.03 | 4.57 ± 1.73 |
Layer V | 4.09 ± 0.90 | 4.51 ± 1.72 |
Layer VI | 3.93 ± 0.89 | 4.44 ± 1.72 |
Auditory cortex | Â | Â |
Layer I | 4.09 ± 1.36 | 4.51 ± 1.29 |
Layer IV | 4.07 ± 1.23 | 4.11 ± 1.22 |
Layer VI | 3.62 ± 1.21 | 3.82 ± 1.18 |
Visual cortex | Â | Â |
Layer I | 3.44 ± 1.10 | 4.17 ± 1.37 |
Layer IV | 3.92 ± 1.24 | 4.52 ± 1.35 |
Layer VI | 3.77 ± 1.14 | 4.38 ± 1.30 |
Preoptic area (LPO/MPO) | 3.39 ± 0.76 | 3.48 ± 1.12 |
Suprachiasmatic nu | 3.55 ± 0.90 | 3.73 ± 1.18 |
Globus pallidus | 3.28 ± 0.71 | 3.83 ± 1.38 |
Bed nu striaterminalis | 3.44 ± 0.76 | 3.58 ± 1.15 |
Olfactory tubercle | 4.41 ± 1.06 | 4.39 ± 1.34 |
Diagonal band | Â | Â |
Dorsal | 4.36 ± 1.07 | 3.92 ± 1.31 |
Ventral | 4.11 ± 1.05 | 3.80 ± 1.36 |
Amygdala basolat/med | 3.95 ± 0.86 | 3.65 ± 0.96 |
Hippocampus | Â | Â |
CA1 | 3.91 ± 0.85 | 3.36 ± 0.77 |
CA2 | 4.00 ± 0.91 | 3.41 ± 0.80 |
CA3 | 4.11 ± 0.92 | 3.69 ± 0.86 |
Dentate gyrus | 4.29 ± 0.99 | 4.18 ± 1.05 |
SLM | 4.49 ± 1.01 | 4.91 ± 1.92 |
Accumbens nucleus | 3.45 ± 0.83 | 3.33 ± 1.16 |
Caudate putamen | Â | Â |
Dorsal | 4.33 ± 1.00 | 3.67 ± 1.40 |
Ventral | 4.35 ± 1.09 | 3.80 ± 1.29 |
Lateral | 4.39 ± 1.00 | 3.76 ± 1.34 |
Medial | 4.36 ± 1.04 | 3.68 ± 1.32 |
Septal nucleus lateral | 3.90 ± 0.88 | 3.31 ± 1.20 |
medial | 4.19 ± 1.01 | 3.84 ± 1.15 |
Diencephalon | Â | Â |
Habenular nu lateral | 5.50 ± 1.15 | 5.75 ± 1.85 |
Habenular nu medial | 5.48 ± 1.67 | 5.12 ± 1.60 |
Lateral geniculate nu dorsal | 4.61 ± 1.91 | 4.19 ± 1.16 |
Medial geniculate nu | 4.59 ± 1.81 | 4.83 ± 1.61 |
Thalamus | Â | Â |
Ventroposterior lateral nu | 4.78 ± 2.14 | 4.08 ± 0.96 |
Ventroposterior medial nu | 4.99 ± 2.15 | 4.31 ± 1.06 |
Paratenial nu | 4.61 ± 0.88 | 4.46 ± 1.76 |
Anteroventral nu | 5.91 ± 1.26 | 5.84 ± 2.41 |
Anteromedial nu | 4.95 ± 1.11 | 4.61 ± 1.77 |
Reticular nu | 4.98 ± 1.09 | 4.93 ± 2.08 |
Paraventricular nu | 4.41 ± 0.87 | 4.23 ± 1.68 |
Parafascicular nu | 4.88 ± 1.31 | 4.85 ± 1.70 |
Subthalamic nucleus | 4.77 ± 1.47 | 4.93 ± 1.71 |
Hypothalamus | Â | Â |
Supraoptic nu | 5.09 ± 1.47 | 5.34 ± 1.41 |
Lateral | 3.89 ± 0.93 | 3.75 ± 1.29 |
Anterior | 3.91 ± 1.00 | 3.90 ± 1.25 |
Periventricular | 3.40 ± 1.00 | 3.29 ± 1.05 |
Arcuate | 4.32 ± 1.20 | 4.66 ± 1.79 |
Ventromedial | 4.03 ± 1.13 | 4.54 ± 1.87 |
Posterior | 4.52 ± 0.92 | 4.01 ± 1.43 |
Mammillary nucleus | 3.99 ± 1.62 | 4.59 ± 1.48 |
Zone Incerta | 4.36 ± 1.40 | 4.18 ± 1.27 |
Mesencephalon | Â | Â |
Interpeduncular nucleus | 5.09 ± 1.42 | 5.89 ± 2.18 |
Substantianigra | 3.50 ± 0.99 | 4.45 ± 1.75 |
Pretectal area | 4.07 ± 1.18 | 4.92 ± 1.92 |
Superior colliculus | 4.17 ± 1.07 | 5.38 ± 2.28 |
Deep layers | 4.05 ± 1.25 | 4.71 ± 1.12 |
Inferior colliculus | 6.62 ± 2.06 | 7.01 ± 2.52 |
Rhombencephalon | Â | Â |
Flocculus | 5.67 ± 1.68 | 6.16 ± 2.24 |
Cerebellar gray matter | 5.58 ± 1.65 | 6.59 ± 2.31 |
Molecular layer cerebellar | Â | Â |
gray matter | 6.54 ± 1.45 | 7.23 ± 2.96 |
White matter | Â | Â |
Corpus callosum | 2.74 ± 0.68 | 2.74 ± 1.08 |
Internal Capsule | 3.19 ± 0.78 | 3.30 ± 1.02 |
Cerebellar white matter | 4.56 ± 1.67 | 5.38 ± 1.83 |
Non-blood–brain barrier regions |  |  |
Subfornical organ | 4.02 ± 0.93 | 4.72 ± 3.10 |
Median eminence | 5.03 ± 1.87 | 5.44 ± 1.73 |
Choroid plexus | 15.89 ± 6.07 | 16.66 ± 6.90 |