Skip to main content
Figure 1 | BMC Neuroscience

Figure 1

From: Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosis

Figure 1

A representative figure depicting the genomic region of Cadherin 13 gene affected by olanzapine. A) Manhattan plot showing the significance of methylation enriched regions. Red box shows DNA methylation enriched region containing subset of CpG sites overlapping with the promoter region of Cdh13 on Chromosome 19, in olanzapine treated cerebellum compared to control (upper panel), while there was no methylation enriched subset of CpGs at that particular genomic region in the control cerebellum compared to treated cerebellum sample (lower panel) B) Red box shows the gene name and the promoter region affected by olanzapine-induced DNA methylation, obtained from Rat Genome Database, C) Part of the promoter sequence entirely affected by olanzapine-induced DNA methylation, and the CTCF binding site sequence is highlighted in red.

Back to article page