Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats

Table 1 Metabolic parameters of fa/fa (obese) rats and their age matched controls

Rats	Weight [g]	Leptin [ng/ml]	Insulin [ng/ml]	Glucose [mmol/l]	QUICKI
Young control	257 ± 14,17	2,02 ± 1,23	0,50 ± 0,24	6,00 ± 0,42	0,537 ± 0,071
Young fa/fa	386 ± 13,68***	36,72 ± 5,20**	6,26 ± 2,14**	6,27 ± 0,63	0,234 ± 0,008*
Old control	457 ± 21,38***	6,33 ± 1,72	1,43 ± 0,38	6,38 ± 0,43	0,274 ± 0,010
Old fa/fa	683 ± 48,31^{###, ooo}	88,66 ± 32,71^{###, ooo}	12,96 ± 4,50^{###, ooo}	6,80 ± 0,51	0,216 ± 0,007^o

Data are mean ± SD, n = 6 animals per group. Significance is *P < 0,05, **P < 0,01 and ***P < 0,001 (*vs. young control rats, ^#vs. young fa/fa rats, ^ovs. old control rats) using two-way ANOVA, Bonferroni post hoc test.
Significance P<0.05, P<0.01, or P<0.001 is illustrated by one, two, or three symbols, respectively. Particular symbols are for particular groups compared.

ISSN: 1471-2202