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Figure 6 | BMC Neuroscience

Figure 6

From: Differential sleep-promoting effects of dual orexin receptor antagonists and GABAAreceptor modulators

Figure 6

The combination of DORA-22 and eszopiclone exhibits non-additive effects relative to either agent alone. Vehicle (vitamin E TPGS, 20% solution, orally), DORA-22 (30 mg/kg), and eszopiclone (10 mg/kg) were dosed alone, or DORA-22 and eszopiclone were administered concomitantly in rats (n = 14) during the active phase (ZT 17:00, gray bar) in the following paradigm: 3 consecutive days of vehicle, 3 days of eszopiclone alone, 3 days of eszopiclone plus DORA-22, and 3 days of DORA-22 alone. Data from all days of each condition were averaged and plotted in 30-min intervals. A. Comparison of responses to DORA-22 (closed symbols) relative to the combination of DORA-22 plus eszopiclone (open symbols). B. Comparison of responses to eszopiclone (closed symbols) relative to the combination of DORA-22 plus eszopiclone (open symbols). Significant differences at 30-min intervals were determined using a linear mixed-effects model for repeated measures t-test, where significant responses are indicated by gray lines and tic marks indicate significance level (short, medium, long, P < 0.05, 0.01, 0.001).

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