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Table 1 Nerve regeneration after nerve injury and repair in healthy and diabetic rats

From: Gender differences in nerve regeneration after sciatic nerve injury and repair in healthy and in type 2 diabetic Goto-Kakizaki rats

  Healthy male Healthy female Diabetes male Diabetes female p-values (KWa) Fisher’s methodb
(n = 10) (n = 10) (n = 10) (n = 10)   Male/female Healthy/Diabetes
Axonal outgrowth (neurofilaments, mm) 7.0 (6.8-7.3) 6.3 (6.1-6.4) 6.9 (6.7-7.1) 5.8 (5.1-6.2) 0.0001 <0.0001 0.02
ATF-3 (% of total) SNL 17.8 (17.6-18.4) 17.6 (16.7-18.0) 19.8 (19.1-21.1) 16.4 (15.7-17.3) 0.0001 0.0001 0.001
ATF-3 (% of total) SND 19.2 (17.7-19.6) 19.5 (18.9-20.1) 18.7 (16.9-20.1) 15.2 (14.4-15.7) 0.0001 0.0003 0.001
Cleaved caspase-3 (% of total) SNL 5.2 (2.6-7.8) 3.1 (2.9-3.4) 9.6 (8.7-11.6) 7.0 (6.4-10.1) 0.0001 0.31 <0.0001
Cleaved caspase-3 (% of total) SND 2.7 (2.2-4.0) 2.5 (2.4-2.7) 6.4 (4.5-7.1) 5.8 (4.3-6.1) 0.0001 0.39 <0.0001
Total cell number (mm 2 ) SNL 1137 (1127-1142) 1050 (1027-1066) 1073 (1046-1103) 1089 (1059-1098) 0.0001 0.0007 0.0001
Total cell number (mm 2 ) SND 1137 (1122-1152) 1112 (1068-1147) 1053 (1019-1091) 1093 (1045-1102) 0.0001 0.07 <0.0001
Preoperative B-glucose (mmol/l) 4.6 (4.3-4.9) 3.90 (3.8-4.3) 15.0 (13.3-17.2) 10.3 (9.7-11.7) 0.0001 <0.0001 <0.0001
Weight increase (%) 2.2 (0.7-2.7) 2.4 (1.3-4.8) 2.0 (1.2-2.6) 2.6 (2.0-3.2) 0.34 - -
  1. Values are median 25th (Q1) -75th (Q3) percentiles. aKW = Kruskal-Wallis. bFisher’s method for independent samples based on the chi square distribution. SNL = Lesion site. SND = Distal nerve segment. Total cell = DAPI stained cells. P-values in bold is significantly different at least at the 0.05 level.