Groups | P-value | ||||||
---|---|---|---|---|---|---|---|
Control (n = 6) | 1-week (n = 6) | 2-weeks (n = 6) | 3-weeks (n = 6) | 90-days (n = 6) | |||
VEGF expression level in occipital cortex* | - | 1 | 0 | 0 | 1 | 1 | <0.001 |
± | 5 | 0 | 0 | 5 | 5 | ||
+ | 0 | 6 | 1 | 0 | 0 | ||
++ | 0 | 0 | 5 | 0 | 0 | ||
VEGF expression level in vessels in pia mater* | - | 2 | 0 | 0 | 1 | 2 | <0.001 |
± | 4 | 0 | 0 | 5 | 4 | ||
+ | 0 | 6 | 2 | 0 | 0 | ||
++ | 0 | 0 | 4 | 0 | 0 | ||
VEGF expression level in superior sagittal sinus† | - | 1 | 0 | 0 | 0 | 1 | 0.004 |
± | 5 | 4 | 0 | 2 | 0 | ||
+ | 0 | 2 | 6 | 4 | 5 | ||
++ | 0 | 0 | 0 | 0 | 0 | ||
VEGF expression level in vessels in dura mater | - | 1 | 0 | 0 | 0 | 1 | 0.002 |
± | 5 | 5 | 1 | 1 | 0 | ||
+ | 0 | 1 | 5 | 5 | 5 | ||
++ | 0 | 0 | 0 | 0 | 0 | ||
HIF-1α expression level in cortex of occipital lobe‡ | - | 2 | 0 | 0 | 1 | 0 | <0.001 |
± | 4 | 0 | 1 | 5 | 6 | ||
+ | 0 | 0 | 5 | 0 | 0 | ||
++ | 0 | 2 | 0 | 0 | 0 | ||
+++ | 0 | 4 | 0 | 0 | 0 | ||
HIF-1α expression level in vessels in pia mater‡ | - | 0 | 0 | 0 | 2 | 1 | <0.001 |
± | 6 | 0 | 1 | 4 | 5 | ||
+ | 0 | 0 | 5 | 0 | 0 | ||
++ | 0 | 1 | 0 | 0 | 0 | ||
+++ | 0 | 5 | 0 | 0 | 0 | ||
HIF-1α expression level in superior sagittal sinus‡ | - | 2 | 0 | 0 | 0 | 1 | <0.001 |
± | 4 | 0 | 1 | 1 | 5 | ||
+ | 0 | 0 | 5 | 5 | 0 | ||
++ | 0 | 2 | 0 | 0 | 0 | ||
+++ | 0 | 4 | 0 | 0 | 0 | ||
HIF-1α expression level in dura mater‡ | - | 2 | 0 | 0 | 0 | 1 | <0.001 |
± | 4 | 0 | 1 | 2 | 5 | ||
+ | 0 | 0 | 5 | 4 | 0 | ||
++ | 0 | 2 | 0 | 0 | 0 | ||
+++ | 0 | 4 | 0 | 0 | 0 |