Figure 1

Diffusion of PKC along a dendrite with no spines (α = 1) or high spine density (α = 0.4). (A) Spatial profile of PKC at t = 1 sec after release at × = 0, the anomalous diffusing PKC remains longer and with higher amplitude than the normally diffusing molecule. (B) The logarithmic transformation of the amplitude decay at × = 0 from the simulations in A show that the anomalous diffusing PKC stays activated longer than the normally diffusing PKC.