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Figure 7 | BMC Neuroscience

Figure 7

From: A novel phenoxy thiophene sulphonamide molecule protects against glutamate evoked oxidative injury in a neuronal cell model

Figure 7

B355252 restores glutamate-evoked reduction of ERK3 expression in HT-22 cells. Cultured cells were treated with glutamate, with and without B355252. Cell lysates were prepared, subjected to SDS-PAGE, and immunoblotted with ERK3 specific antibody. Membrane was reprobed with anti-GAPDH and used to normalize gel loading. The bar graph shows the relative levels of Erk3 in the samples. Glutamate-dependent attenuation of ERK3 was reversed by treatment with B355252 (8 μM). B355252 exclusively had no significant effect on the basal level of ERK3 (***p<0.001 compared to glutamate-treated cells).

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