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Figure 2 | BMC Neuroscience

Figure 2

From: A novel phenoxy thiophene sulphonamide molecule protects against glutamate evoked oxidative injury in a neuronal cell model

Figure 2

Neuroprotective effects of B355252 against glutamate-induced toxicity. HT-22 cells were treated with or without glutamate and the indicated concentrations of B355252 and analyzed with the MTT assay (A), or a fluorescent viability assay (B, C, D). (A). B355252 conferred significant dose-dependent protection against glutamate toxicity compared to the untreated control. B355252 also displayed cell proliferative effect in the absence of glutamate (*p<0.05, ***p<0.001 compared to glutamate-treated cells; ###p<0.001, +++p<0.001 compared to control). Representative morphology of glutamate treated cells (B), cells protected from glutamate toxicity by B355252 (C), and untreated control cells (D).

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