TY - JOUR AU - Hermann, Petra M. AU - Park, Deborah AU - Beaulieu, Emily AU - Wildering, Willem C. PY - 2013 DA - 2013/08/06 TI - Evidence for inflammation-mediated memory dysfunction in gastropods: putative PLA2and COX inhibitors abolish long-term memory failure induced by systemic immune challenges JO - BMC Neuroscience SP - 83 VL - 14 IS - 1 AB - Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 (PLA2), an enzyme mediating the release of fatty acids such as arachidonic acid that form the precursor for a variety of pro-inflammatory lipid metabolites. This study investigated the effect of biologically realistic challenges of L. stagnalis host defense response system on LTM function and potential involvement of PLA2, COX and LOX therein. SN - 1471-2202 UR - https://doi.org/10.1186/1471-2202-14-83 DO - 10.1186/1471-2202-14-83 ID - Hermann2013 ER -