Skip to main content
Figure 5 | BMC Neuroscience

Figure 5

From: Contribution of different classes of glutamate receptors in the corticostriatal polysynaptic responses from striatal direct and indirect projection neurons

Figure 5

Differences between dSPNs and iSPNs observed during corticostriatal synaptic integration are undetectable during intrastriatal stimulation. A: Corticostriatal responses evoked with increasing stimulus strengths until suprathreshold responses reach repetitive firing in a dSPN (red record). B: Responses to intrastriatal stimulation with the same stimulus in the same dSPN. Inset: scheme illustrating positions of stimulation electrodes. C: Corticostriatal responses evoked with increasing stimulus strengths until suprathreshold responses reach a brief spike burst in an iSPN (green record). Inset: a superimposition of corticostriatal responses in dSPNs and iSPNs. D: Responses to intrastriatal stimulus evoked with the same stimulus. Inset: a superimposition of suprathreshold responses to intrastriatal stimulus in dSPN and iSPN neurons. E: Superimposition of responses to cortical and intrastriatal stimulus in dSPNs. F: Superimposition of responses to cortical and intrastriatal stimulus in iSPNs. G: Histograms comparing response areas, amplitudes, and duration at half amplitude (mean ± SEM). Note that only corticostriatal responses allow distinguish between dSPNs and iSPNs.

Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us