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Table 4 Permeability of CNS and non-CNS crossing small molecules across RBEC and RSCEC monolayers grown on Millipore cell culture inserts

From: Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitromodels of the rat blood-brain barrier and blood-spinal cord barrier

  

RBECs

RSCECs

 

Passive transport into CNS?

Number of inserts

Mean Pe (×10-6 cm/sec)

SEM (×10-6 cm/sec)

Number of inserts

Mean Pe (×10-6 cm/sec)

SEM (×10-6 cm/sec)

Atenolol

No

15

16.53

2.939

6

9.788

3.166

Caffeine

Yes

9

394.9

60.46

6

376.4

81.13

Hydroxyzine

Yes

8

234.3

42.92

nd

nd

nd

Lucifer yellow

No

15

3.37

0.328

6

1.734

0.0734

Methotrexate

No

15

24.26

9.164

6

3.458

0.3547

Propanolol

Yes

15

198.8

22.16

6

246.5

47.94

Risperidone

Yes

11

143.1

22.54

6

184.5

29.01

Sulpiride

No

15

26.41

5.003

6

10.29

1.157