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Figure 1 | BMC Neuroscience

Figure 1

From: Antisense-mediated isoform switching of steroid receptor coactivator-1 in the central nucleus of the amygdala of the mouse brain

Figure 1

Schematic representation of the mRNA of the two SRC-1 splice variants. Boxes represent exons and thicker full lines represent introns. Dashed lines indicate possible splicing events. The approximate position of stop codons is also marked. If exon 22 is included, SRC-1e is expressed. Exon 22 contains an earlier stop codon, therefore SRC-1e protein is shorter than SRC-1a. AONs targeting exon 22 can render it inaccessible to the splicing machinery and therefore, shift the expression of SRC-1 towards SRC-1a. (Adapted from Kalkhoven et al. [23]).

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