Effect of CHF5074 and DAPT treatments on microglia activation. A-D. Representative images of Iba1-immunostaining of activated microglia in hippocampus sections from wild-type (A) and Tg2576 vehicle- (B) and CHF5074-(C, D)-treated animals; # indicates the animal code. E. Quantification of Iba1-immunostaining of activated microglia in the different treatment groups. CHF5074, but not DAPT, reduces the level of microglial activation observed in Tg2576 mice. **p < 0.01 vs vehicle-treated Tg2576 mice.