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Table 3 Regression formula for hypotheses 1B and 2B

From: Method parameters’ impact on mortality and variability in rat stroke experiments: a meta-analysis

Regression formula for the effect of Strain and Type of middle cerebral artery occlusion procedure on Mortality rate (hypotheses 1B and 2B)

Variable (reference category)

Variable categories

Regression coefficient

0.95 confidence interval for regression coefficient

p-value

Constant

NA

17.1

13.9

20.3

0.000

Strain (Sprague Dawley)

Wistar

1.0

−2.4

4.4

0.551

SHR

−6.9

−12.8

-.87

0.025

WKY

−8.3

−19.3

2.8

0.141

Other Strains

4.4

−1.1

9.9

0.113

Type of middle cerebral artery occlusion procedure (Intraluminal filament)

Direct, mechanical

−10.7

−15.1

−6.2

0.000

Embolic

12.1

6.9

17.3

0.000

Photothrombotic

−5.6

−15.3

4.2

0.262

Endothelin injection

−9.7

−16.8

−2.6

0.007

Type of anesthetic (Inhalation anesthetic)

Chloral Hydrate

4.1

0.17

8.1

0.041

Ketamine

3.2

−1.1

7.4

0.144

Barbiturates and bensodiazepines

1.1

−4.6

6.8

0.710

Other anesthetic

3.0

−1.9

8.0

0.230

Awakening of rats during occlusion (No)

[Yes]

9.1

3.9

14.2

0.001

Heart rate monitored (No)

[Yes]

−3.3

−7.5

0.94

0.127

Blood glucose concentration analyzed (No)

[Yes]

−2.8

−6.1

0.53

0.099

Type of infarct size evaluation (TTC)

Radiology

5.4

−0.11

10.9

0.055

Acidic/Basic stain or silver stain histology

−1.2

−4.7

2.4

0.526

Immunohistology

10.4

3.2

17.6

0.005

Criteria for excluding rats (None)

Observed absence of cerebral blood flow reduction

−4.0

−6.9

−1.1

0.008

Lack of functional deficit

0.15

−3.4

3.7

0.933

Too small infarct

0.22

−5.1

5.6

0.935

Other pathology in animal

−3.4

−7.1

0.40

0.079

  1. Variables excluded by statistical software due to too low explanatory value: Sex, Elderly rats, Weight, Intubation, Temperature feedback system, Blood pressure monitored, Blood gases/O2 saturation analyzed, Blood hemoglobin concentration analyzed, Postoperative antibiotics, Occlusion duration, Time after focal ischemia for evaluation of damage, Edema correction used, Blinding of infarct size determination procedure.