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Figure 1 | BMC Neuroscience

Figure 1

From: Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation

Figure 1

LC-MS/MS analysis of domoic acid. Intraperitoneally administered DA (1 mg/kg) was identified and quantified in the rat brain by LC-MS/MS analysis. (A) Accumulated reconstructed ion chromatograms of the three product ions (m/z 312 → 248, 266, 294) having a retention time of 8.3 min and (B) MS/MS spectrum for a 10 ng/ml standard solution of DA. (C) A brain sample from a rat taken at 30 min after intraperitoneal DA administration (1 mg/kg) showing the same retention time as that of the standard DA and (D) the presence of three diagnostic fragment ions.

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