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Table 2 Electrophysiological measures of spiking and bursting activity from mature and immature cortical cultures

From: Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays

Age Spikes per channel during global bursts Spikes on all channels during global burst Active channels during global bursts Burst duration (channel; ms) Burst duration (global; ms)
  Range Mean ± SEM Range Mean ± SEM Range Mean ± SEM Range Mean ± SEM Range Mean ± SEM
i 9-23 13 ± 1* 70-592 264 ± 43 7-38 19 ± 2* 20-80 50 ± 5 80-190 140 ± 8*
m 6-20 11 ± 1 35-374 140 ± 22 5-20 12 ± 1 20-50 40 ± 3 40-160 100 ± 1
  In-burst ISI (ms) Overall ISI (ms) Proportion of spikes in bursts (%) Inter-burst interval (s)  
Range Mean ± SEM Range Mean ± SEM Range Mean ± SEM Range Mean ± SEM   
i 2-9 4.6 ± 0.5 13-61 33 ± 4 28-93 56 ± 6.5 1.9-30.1 7.3 ± 2.0   
m 2-6 4 ± 0.3 22-79 44 ± 4 26-91 58 ± 4.8 0.9-27.2 5.1 ± 1.5   
  1. Data are presented as minima and maxima ranges and means ± SEM. ‘m’ and ‘i’ represent mature and immature cultures respectively (see Methods). * indicates significant differences (P ≤ 0.05) between mature and immature cultures for a given measure.