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Table 2 Electrophysiological measures of spiking and bursting activity from mature and immature cortical cultures

From: Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays

Age

Spikes per channel during global bursts

Spikes on all channels during global burst

Active channels during global bursts

Burst duration (channel; ms)

Burst duration (global; ms)

 

Range

Mean ± SEM

Range

Mean ± SEM

Range

Mean ± SEM

Range

Mean ± SEM

Range

Mean ± SEM

i

9-23

13 ± 1*

70-592

264 ± 43

7-38

19 ± 2*

20-80

50 ± 5

80-190

140 ± 8*

m

6-20

11 ± 1

35-374

140 ± 22

5-20

12 ± 1

20-50

40 ± 3

40-160

100 ± 1

 

In-burst ISI (ms)

Overall ISI (ms)

Proportion of spikes in bursts (%)

Inter-burst interval (s)

 

Range

Mean ± SEM

Range

Mean ± SEM

Range

Mean ± SEM

Range

Mean ± SEM

  

i

2-9

4.6 ± 0.5

13-61

33 ± 4

28-93

56 ± 6.5

1.9-30.1

7.3 ± 2.0

  

m

2-6

4 ± 0.3

22-79

44 ± 4

26-91

58 ± 4.8

0.9-27.2

5.1 ± 1.5

  
  1. Data are presented as minima and maxima ranges and means ± SEM. ‘m’ and ‘i’ represent mature and immature cultures respectively (see Methods). * indicates significant differences (P ≤ 0.05) between mature and immature cultures for a given measure.